Definition and Overview

There are three major salivary glands in the body: the parotid, submandibular, and sublingual glands. Just like any other part of the body, these glands can also develop tumours. The majority of salivary gland tumours are found in the parotid gland but most of them are benign. Meanwhile, half of the masses discovered in the submandibular and sublingual glands turn out to be malignant. Management of these masses entails the removal of the gland via surgery.

Who Should Undergo and Expected Results

Tumour excision is an important aspect in the management of patients with masses of the submandibular gland. Malignant tumours of the submandibular gland may range from low to high grade, and activity depends on the kind of tumour and the stage. Commonly encountered submandibular gland tumours are adenoid cystic carcinoma and mucoepidermoid carcinoma.

Tumours of the submandibular gland usually manifest as a palpable mass on the neck. Pain may also be an associated symptom as well as invasion of the nerves, particularly the hypoglossal nerve, which may result in paralysis.

Low-grade tumours generally have a good prognosis, with 5-year survival rates reaching up to 70%. High-grade tumours, on the other hand, do not have as good a prognosis. In certain cases that involve nerve invasion and regional metastases, radiation therapy may be indicated postoperatively.

Another indication for submandibular gland excision is the chronic inflammation of the gland due to the formation of stones. Rarely, patients who experience trauma to the submandibular area may also require excision of the submandibular gland.

How is the Procedure Performed?

Submandibular gland excision is performed with the patient asleep under general anaesthesia, with the head rotated to the side opposite the tumour. The basic principle employed in this procedure is en bloc removal of the entire gland, including the submandibular lymph nodes, with preservation of nerves, if possible.

Operations in the submandibular area begin with a curvilinear incision along the mandible, starting from the midline to the mastoid process (near the ear). A flap is then created under the platysma muscle, which remains attached to the skin. The facial nerve, specifically its marginal branch, is then identified, located immediately underneath the muscle. The nerve should be preserved unless the tumour has also invaded it.

The gland is then gently dissected, beginning at the level of the hyoid bone. The hypoglossal nerve is identified, which is located between the digastric muscle and the gland itself. The lingual nerve is likewise identified, which can be found upon the retraction of the mylohyoid muscle.

Dissection is continued up to the facial artery, which serves as the blood supply to the submandibular gland. The artery is ligated, making sure to have an adequate margin just in case the artery retracts under the digastric muscle. The excision of the submandibular gland is completed with the ligation of the Wharton duct.

Some surgeons send the specimen for frozen section biopsy to determine if the resected margins are adequate. The specimen is examined while the patient is still in the operating theatre, and a decision is made based on the histologic findings. More extensive resections may be required if other adjacent structures, such as the mandible, are affected. Meanwhile, the presence of enlarged lymph nodes in the neck may require further neck dissection during the same operation.

Finally, a drain is inserted and closure is performed in layers. A sterile dressing is applied to the wound afterwards.

Possible Risks and Complications

The excision of the submandibular gland requires a thorough knowledge of head and neck anatomy, as a number of important structures can be found in this area. Injuries to these vital structures can result in significant and permanent morbidity.

One of the most serious and disabling complications of the procedure is an injury to the nerves, particularly the facial nerve, the hypoglossal nerve or the lingual nerve. Approximately 10-30% of cases end up with facial paralysis or paresis after the operation. Most of these cases are temporary and are due to the stretching of the facial nerve during dissection or to inflammation after the operation and usually resolve within a few weeks to months. However, 7-12% of these cases result in permanent facial paralysis, leading to the inability to move the muscles of the face near the lips. Permanent damage to the lingual and hypoglossal nerves occur less frequently (2-5%). Occasionally, the nerves need to be sacrificed due to direct involvement with the tumour. In these cases, immediate nerve grafting during the operation may be necessary.

Aside from nerve injury, other complications of the procedure include infection and wound-related problems, such as scar formation. Bleeding and hematoma formation can be minimised with proper hemostasis while the application of compressive dressings and use of drains minimise the risk of seroma formation. Tumour recurrence is also a possibility, and may be associated with inadequate excision or margins of resection. The development of salivary fistulae has also been reported. In some benign conditions, chronic inflammation of the area may occur due to residual stones in the salivary ducts.

References

  • Strympl P, Kodaj M, Bakaj T, Kominek P, Starek I, Sisola I, et al. Color Doppler Ultrasound in the pre-histological determination of the biological character of major salivary gland tumors. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Sep 5.

  • Witt BL, Schmidt RL. Ultrasound-guided core needle biopsy of salivary gland lesions: a systematic review and meta-analysis. Laryngoscope. 2014 Mar. 124 (3):695-700.

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